Flea and tick are the most common problem that pets face. These nasty parasites cause discomfort, skin irritation and even lead to wide range of diseases like flea allergy dermatitis (FAD), anemia or other internal parasites including tapeworm, and rickettsiosis. With those conditions, your pet feels lethargic, and faces lot of problems. It adversely affects his health in numerous ways. Most pet owners search for the best ways to remove these flea and ticks. Among the wide range of flea and tick treatments available in the market, Frontline Plus is the most popular and highly effective. Moreover, many veterinarians also recommend this topical solution for treating the harmful flea infestations. However, while purchasing this flea and tick spot-on treatment online, many pet owners are confused between Frontline Plus and Frontline Combo. They are placed in the dilemma whether to buy ‘Plus’ pack or ‘Combo’ pack, what is the difference between them, and which is the most effective one that fights against fleas and ticks. Well, to clear all your confusion, we present here the solution for this “frequently asked question”, with a short description about each product and help you understand the difference between them. Frontline Combo Frontline Plus is known as Frontline Combo in U.K. and Europe. Frontline Combo is a prescription medication in the U.K. It is widely used to treat and control fleas and ticks. As many fleas are resistant to original Frontline available in the U.K market, Frontline Combo works effectively. It stops the fleas laying eggs, and breaks the lifecycle of fleas. Furthermore, it disrupts the other flea life stages around the house through pet hair, which has been induced with life stage inhibitors, when you treat the pet to kill the adult fleas. Manufactured by the brand company Merial to kill fleas at all stages, Frontline Combo further prevents recurrence of fleas and ticks on your pets. It effectively controls flea and tick on dogs and cats, puppies and kittens helping them to stay healthy year round. Additionally, Frontline Combo is widely popular due to its scientific proven methodology that kills flea eggs and flea larvae further preventing re-infestation in dogs and cats. Not only for fleas, but Frontline Combo is also designed to fight against all stages of ticks including brown dog tick, the American dog tick, lone star tick and deer ticks, (which is the major carrier of Lyme disease). Frontline Combo shows the same benefits as the Frontline Plus whereas the difference lies in their names depending on the countries where they are sold. Frontline Plus Frontline Plus is a flea and tick treatment available in the U.S. This over-the-counter medication is the most popular topical solution for treating fleas and ticks. It removes fleas along with ticks and lice on pets. Further, it stops flea infestation by killing adult fleas and acts as flea repellant. More importantly, it does not just kill adult fleas and ticks but destroys the next generation of flea eggs and larvae. Frontline Plus is highly recommended by veterinarians due to its powerful effect in protecting dogs from infestation for longer period. It continuously has its effect for a month on dogs and cats. Some of the most important features of Frontline Combo & Frontline Plus are:
Frontline Plus, the American version and Frontline Combo, sold in Europe, contains fipronil and the insect growth regulator (IGR) (S)-methoprene. These active ingredients effectively target all stages of fleas. Fipronil stays in the oils of the skin and hair follicles, and continues to be released from hair follicles onto the skin and coat, resulting in long-lasting activity against fleas, ticks and chewing lice. Find Below What is the difference between Frontline Plus Vs. Frontline Combo for Dogs? Frontline for Dogs: USA Version –
UK Version –
Matt B.
12/9/2014 10:19:54 pm
Ok, so all that to basically say one is the European brand that meets EEA standards. But both can be bought via the internet. Unless you're a scientist, the quantities mentioned are like comparing apples and oranges. The layperson just needs to know if one is more effective and safer for pets. There is a big price variance between the two and knowing those differences helps determine value.
Carrie
7/3/2016 05:40:37 pm
Thank you!! For the math I mean. I was giving it the old college try to figure out the proportions but you did it for me successfully.
David
9/22/2016 04:01:55 pm
I *highly* doubt that there is actually ANY difference at all. They just rounded the figures.
Dee
1/5/2015 01:09:04 am
The combo does not work like Frontline plus. I'll never waste my money again on it......
FurryOne
3/27/2015 08:59:50 am
Hmmm... They BOTH contain the SAME ingredients, so are you a shrill or just stupid?
Agu Deza
6/15/2015 08:50:54 am
I for one agree there could still be a difference in how well each of them may work when compared. The only info shared was the fact that active ingredients are the same. So I guess your an expert, which still does not mean you know it all. To know it all is to learn nothing. To criticize others as if they don't know it all is just plain arrogance.
Nina
7/20/2015 10:08:12 am
Why would you call someone stupid you piece of shit. You must be really miserable and ugly to call someone you don't know stupid. It shows how much of an ARSE that's ASS you are. FURRY ONE? Yeah a hairy arse
Vforvendeta
10/24/2015 04:22:34 pm
Nina, Why would you call someone piece of shit? You must be really miserable and ugly to call someone you don't know "piece of shit." It shows how much of an ARSE that's ASS you are. Nina? Yeah a hairy hypocrite
dave
12/2/2015 08:57:58 pm
does it work on pieces of Shit like Nina that can tell what someone looks like without ever seeing them ?
rick
12/20/2015 01:46:26 pm
even though the ingredients are the same the amounts are different. It looks like the UK version is stronger.
k9mama27
4/27/2016 01:11:02 pm
Maybe you bought a counterfeit? The ingredients are the same so, unless you purchased it somewhere other than a vet or reputable dealer, there's an excellent chance you got ripped off. As much as we all want to save money there are plenty of counterfeit products out there sold by piece of shit ppl. 😂😂😂😉 Competing companies,(Not just in this instance, but w/all types of items) claim they have the same "active ingredient(s)", so most people automaically think they are exact thing just different prices. Truth is the average active ingedient % of an item is well below 5%. So there is 95%+ that could be the cause of the differnce in results.
mary
4/29/2015 03:26:48 pm
Why wouldn't they work the same if there the same ingredences. I not sure if the amounts of the ingredants are the same or not. Are they? Or do they just have different fleas and ticks over there in the uk? 6/11/2015 10:57:32 am
I just recieved my Frontline Combo from the UK,I usually buy Comfortis from Australia, but with an aging dog im afraid to pump heavy poison in her,this site was way more than half the price,got lg dog and cat less than dog , its easier to apply to cats,first round of comfortis cats threw up did not give to aging dog,only 7 year old,still gad fleas,applied yesterday more than 24 hrs ago,still see scratching and fleas , this why I went to comfortis,but determined to not use it at 80 a month,hopefully a build up of it on a reg basis will show better results,Combo has slightly higher main ingredient and is rx only in uk,...will I keep you posted
Helen
6/12/2015 07:51:19 am
If these harsh poisonous chemicals are actually bad for dogs why is it still being sold to the public? I am on a rock and a hard place. Eventhough frontline is very effective it is a slow killer for dogs, I tried using all nutural flea treatments but it's not as effective. I wish there was another option.
Belinda
6/23/2015 03:50:45 pm
Helen,
Tamara
2/23/2016 01:19:56 pm
Belinda,
Pauleen
9/10/2016 02:14:29 am
I used the combo and find my 3 cats are still infested with fleas.
Barbara
4/1/2016 04:37:37 pm
Belinda did the combo work on your cats. I just ordered some
Laurie
7/16/2016 01:54:54 pm
I used both for dog and cats. the plus did not work as well as the combo for me. Four weeks later on the combo and I have no flea worries.
laurie
7/3/2015 02:09:59 pm
I thino what there are saying is pretty much is the uk version is like metric. The US is the ml. Or oz. But it is the same amount of ingred. And real difference is the box or the packaging. Which makes sense because Us is on different measurimg system and i think that Uk been metric or what ever for years. But it is from what they're saying the same amounts. Basic you have a ruler in inches and i have a ruler in metric but it still the same size. I think thats what they're saying. The box looks different. Is that what your getting out of it?
Beth
8/2/2015 08:30:16 am
I have been using the Combo now for 2 months and my cats have fleas SO BAD they are pulling out they're hair. How is it this does not work if same ingredients? Is it because different type of flea or something?
Honey
7/6/2016 04:14:32 pm
Beth, use food grade Diatomaceous Earth on them and in their food. When you put it on, do not create a big puff or cloud of powder, gently stroke it through their hair and down to the skin instead. It isn't good for the lungs when inhaled as dust, but is fine when put on the skin or eaten. It has wonderful health benefits for people also, but it will dry the exoskeleton of bugs and they will just 'poof'. http://www.richsoil.com/diatomaceous-earth.jsp I fostered feral momma cats and they brought in fleas. I was still fighting them for months after the kittens were born and adopted away. I sprinkled this stuff all over the floor, carpet, dogs, cats, etc., and within a week, every flea seemed to have just disappeared!! I haven't seen one since. Good luck!
love all animals
8/24/2016 07:43:58 pm
If you use diatomaceous earth make sure it is "food grade". Also if used on floor, furniture you must not use a regular vacuum after. IT WILL "GO THRU YOUR MOTOR" AND KILL YOUR VACUUM! also, a little goes a really long way. wearing a mask for dust is a good idea for you too when you are applying it. works great in sw Oklahoma.
joypebble
8/7/2015 06:43:58 am
Sweet 'lil' Nina said, "Why would you call someone stupid you piece of shit.."
Lynn
9/11/2015 06:33:17 am
Beth, if you have a very bad flea infestation, it is going to take a lot longer than 2 months to see improvement. We had a terrible infestation in the beginning of last year and it took 5 months at least before we started to see improvement. We are still battling fleas but they are to the point now where we don't find any on us and few on the cats (we have 5 cats). We used Frontline Plus and this is the first time we are trying Combo to reduce the cost because Frontline for 5 cats costs a small fortune. Hang in there and keep treating and you will hopefully see improvement soon!
Bob Deal
12/31/2015 09:04:04 am
Refreshing to see a sensible and credible response in this world of the unknown responds from those who has absolutely no reason or right to even be on the internet. Thank you and let's try to eliminate these people.
Somedude
2/3/2016 08:02:34 pm
0.045 ounces = 1.35 mLiter by standard conversion (ask professor google to do it LOL) so ok yes same that ingredient...and for the other one I would assume that the ratio of 100g/L means what percentage if 100grams are put into 1 Liter of water as other is listed as % so that's the only unknown but think you'd need to know density of their ingredient?
Mark S
4/6/2016 06:38:21 am
Guys - the formulations are IDENTICAL between the US and the EU - as the product weighs 1.02g/ml when expressing the 10% w/v fipronil content as % w/w you would need to divide the 10% (that's 100g/L) by 1.02 = 9.8% w/w, etc. All the excipients and the primary packaging between the two territories are identical, so you should not be seeing differences in efficacy.
Chuck
4/14/2016 02:28:49 pm
We have 2 dogs and 1 cat. In 1994, we had both dogs on Frontline, as we had for years, but not the cat. The cat never went outside, so we thought she did not need it.
Stephen Heaney
4/26/2016 10:59:10 am
Hello all common
Bob Deal
4/27/2016 08:48:56 am
If you know how to multiply and divide and realize that their are different systems used in different countries you will also find that these products sold here and abroad are the same. I wish we had learned and used the simple metric system where anything can be divided by 10. Life is simple that way. All the crap written on here must be from dumb people, by definition. I end my commenting, goodbye to all you who can understand simple math.
k9mama27
4/27/2016 02:50:31 pm
Ok, I'm going to give you all a secret my vet shared with me. I have 8 dogs & 6 cats so you can imagine what it would cost me if I had to buy Frontline for each & every animal. Frontline for a 6 lb dog & a 100 lb dog cost relatively the same price (which is shameful) but, obviously, you get a LOT less product with the smaller dog package than you would with the biggest dog package. Here's what you do ---
AYAMEYXII
4/28/2016 04:35:12 am
Omg, You are the BEST.. Thank You , GOD BLESS....:-)
k9mama27
6/24/2016 06:02:08 pm
You are VERY welcome! God Bless you too! ;)
M page
5/3/2016 06:59:06 am
Fabulous tip! Thank you. I rescue cats and currently have 9, so, this is truly good news. I notice that some folks are relying on Frontline, etc, to initially rid pets of fleas. My vet first gave each cat Capstar (tablet), before Frontline. Capstar apparently kills all existing fleas, but, not future fleas or eggs that cat may have swallowed, which become tape worms. Once Capstar has killed the existing fleas, which takes only about one hour after administering the pill, then Frontline takes over.
k9mama27
6/24/2016 06:06:12 pm
;)
FrenchBoxer
5/3/2016 06:46:50 pm
We've been doing this for 15 years. Saves a TON of money. With a French Bulldog and a Boxer we only have to buy one box of Frontline instead of 2. We share with my neighbor too which saves even more money! Plus, Frontline doesn't expire so you can save it from year to year.
FrenchBoxer
5/3/2016 06:50:02 pm
I think I know your heartworm hack too! I pay $32 total for THREE YEARS of heartworm treatment for THREE dogs. Love when my vet gives me hacks!
k9mama27
6/24/2016 06:03:00 pm
Sounds like you do! ;)
k9mama27
6/24/2016 06:30:23 pm
Just wondering, do you notice using the heartworm hack that it also keeps other bugs like fleas off of your dogs? Just curious cause I do. Even though we use Frontline, we've noticed since starting the heartworm hack that even if we do see a flea here or there, they never take hold of the house. I also have a tapeworm and panacur wormer hack. ;) I'm frugal! Either that or I don't like being ripped off! LOL! If anyone wants my hacks, email me at my user name on the g mail. ;) Put in the subject line Pet Hacks so I know it's not junk mail.
Flylow21
6/10/2016 05:46:48 pm
Thank you so much for your information when you have 16 dogs 14 cats this info helped alot.
k9mama27
6/24/2016 06:04:19 pm
I know the feeling! Lol! You're very welcome! Be Blessed! <3
jennifer
8/5/2016 12:25:21 pm
so can you use frontline plus for big dogs on a cat? and if so how can i find out the dosage for a cat
Deb
8/22/2016 12:59:30 pm
K9mama27...Thank you for that information! I have been buying the bigger ones to split between our dogs for awhile now but never had a conversion rate to be accurate per pound. Making a card with that info is a great idea!
AYAMEYXII
4/28/2016 04:28:43 am
Omg!!! What are we back in HIGH SCHOOL. Folks , people are here to find out info on the quality of the product... I am more CONFUSED ,now. Can someone PLEASE tell with one is better..Thanx...:-)
Scott
5/3/2016 12:32:09 pm
Brand/Name Recognition and marketing. They are the same. Front Line Plus is a bigger name so it's bigger money. The veterinarians I've used all say Front-line Plus in the best. 6/25/2016 06:21:13 am
CAUTION: Although the active ingredients can be identical, it is sometimes the INACTIVE ingredients that may cause the product to work less effectively or even adversely. 7/5/2016 12:03:58 am
I have found that rotating Frontline Plus and Advantage for my cats every six months or so keeps efficacy high. My cats seem to somehow become immune to the type of product after around 6 months of usage, so I switch to the other for the next 5-6 months, and so on--thus switching back an forth. It works for my cats. I have found that Combo ISN'T as effective as the Frontline Plus. I don't get why considering all the math done above, but I noticed it right away the first time I used Combo. Good luck to everyone, and please be kind to each other. There is no need to be nasty to each other. It's hurtful and just plain rude to talk to others like that. I was raised to be kind and you get more bees with honey than you do with vinegar!
Vicki
7/21/2016 11:36:56 am
I believe the Frontline Plus and Combo are exactly the same but in the U.K. the Combo is prescription only whereas the Plus can be bought without a prescription. Comments are closed.
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